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KMID : 1130220220260040372
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Annals of Geriatric Medicine and Research
2022 Volume.26 No. 4 p.372 ~ p.376
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Rapidly Progressive Malignant Pelvic Perivascular Epithelioid Cell Neoplasm (PEComa) Associated with Eggerthella lenta Bloodstream Infection
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Cacciatore Stefano
Recupero Carla
Massaro Claudia
Elmi Daniele
Fusco Domenico
Brandi Vincenzo
Landi Francesco
Arciuolo Damiano
Marazzi Fabio
Badiali Vanessa
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Abstract
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Perivascular epithelioid cell tumors (PEComa) are rare mesenchymal neoplasms composed of cells that express melanocytic and myogenic markers and grow around small blood vessels. PEComa often show benign behaviors but can also be highly aggressive. In frail and more complex patients, many conditions can overlap, compounding the diagnostic and therapeutic difficulties inherent in rare diseases. Moreover, the complexity of modern patients introduces new and significant players in host-microbe interactions, and emerging pathogens represent a relevant challenge to modern healthcare. Among these pathogens is Eggerthella lenta, an anaerobic gram-positive bacterium of the normal gut microbiota associated with life-threatening infections. Here, we present a case of malignant pelvic PEComa with rapid metastatic progression in a 73-year-old man who presented with an E. lenta bloodstream infection. Approaching differential diagnosis with open-mindedness may assist in better imaging interpretation, surgery scheduling, and proper treatment planning. Despite progress in diagnostic techniques for a more accurate pathogen diagnosis and characterization, a good dose of wisdom is vital to avoid overlooking potentially harmful pathogens, particularly in frail individuals.
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KEYWORD
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Perivascular epithelioid cell neoplasms, Eggerthella lenta, Infections, Abdominal abscess, Sepsis, Microbiota, Frailty, Emerging pathogens, Bloodstream infection
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